Lecture Building - 1st floor | Walkthrough Bloodborne Guide
Last update: 11 May 2016
After defeating the One Reborn and touching the mummy in the place that has been unlocked after the battle (the court ahead) you will be automatically transported to the Lecture Building - 1st floor. It is a level connected to the previously visited lower part, but first you must unlock that connection.
First, light up the lamp and open the door to the corridor. There, first go to the round room ahead. Near the body you will find 6x Sedatives. When you leave, watch out for the enemy hanging above the exit.
Then, deeper in the corridor defeat few "students". On the right, on the other side you will find Blood Stone Shard. On the left you can open the door and walk through the upper part of the hall, where you will read a note at the end. Similarly in the room maximally at the left.
In the right part you will face a larger enemy. He fight similarly to enemies with axe, but his attacks are much stronger, and enemy is very resistant. Try to attack mostly when the colossus is temporary uncovered, after he locks his fists in the ground. Attacks are powerful but slow, so avoiding them shouldn't be hard. After the battle, open the door on the right, then walk above the hall and in the room at the end you will find a chest with Communion Rune (increase the maximum amount of Blood Vial you can have at the same time).
Return to the place where you fought the giant enemy. Under the wall, more to the right, you will see a ladder. When you walk down, you can talk to the "spider" that was previously blocking the door below. Talk to him once (you will receive "Beg for Life" gesture, open the door to unlock the passage to the lower part of Lecture Building), then second time - if you confirm that you don't have anything against the spider (second dialogue option), you will receive Anti-Clockwise Metamorphosis Rune which improves your condition by 15%. You can find the spider in some parts of Chalice Dungeons. He sells the item at much higher prices than Messengers in Hunter's Dream.
Finally, you can attack the spider if you are not interested in what he has to offer - if you do this quickly enough, he will not even have the time to react. Otherwise, watch out for the attack similar to the ones that the spiders used while you were fighting Rom, the Vacuous Spider. For killing the spider, you receive 5 443 Blood Echoes and Great One's Knowledge.
Finally return up. Through the door at the end of the corridor you can get to the Nightmare of Mensis location.