Game Guide - Activating the DLC F3: MZ Guide

Make sure that Mothership Zeta has been installed properly on your computer and you'll also have to activate it from the game's autostart. This final fifth add-on is not suitable for players whose characters have just left Vault 101. The best moment in my opinion to begin this new journey is somewhere around 15th-20th level of experience. Thankfully you won't have to worry about taking good equipment for the new mission, because you'll find A LOT of useful guns on board of the mothership. The only real exception is the armor, so I would recommend visiting the Citadel prior to meeting the aliens and learning how to use power armors. Don't forget to collect any equipment you need from your followers, because they won't be abducted and they'll remain in Capitol Wasteland waiting for you to return to them.